All Research Articles

Herxheimer A, Pertrie KJ (2002) Melatonin for the prevention of jet lag. Cochrane Database Syst Revt.9:11-24. Abstract Background: Jet-lag commonly affects air travellers who cross several time zones. It results from the body's internal rhythms being out of step with the day-night cycle at the destination. Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re-align them with the outside world. Objectives: To ass

Seeram NP, Momin RA, Nair MG, Bourquin LD. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries Phytomedicine. 2001 Sep;8(5):362-9. Abstract Anthocyanins from tart cherries, Prunus cerasus L. (Rosaceae) cv. Balaton and Montmorency; sweet cherries, Prunus avium L. (Rosaceae); bilberries, Vaccinum myrtillus L. (Ericaceae); blackberries, Rubus sp. (Rosaceae); blueberries var. Jersey, Vaccinium corymbosum L. (Ericaceae); cranberries var. Early Bla

Keane KM, Bell PG, Lodge JK, Constantinou CL, Jenkinson SE, Bass R, Howatson G. Phytochemical uptake following human consumptionof Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro. Eur J Nutr. 2016 Jun;55(4):1695-705. doi: 10.1007/s00394-015-0988-9. Abstract Purpose: To investigate the phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of selected phe

Hughes RJ, Sack RL, Lewy AJ (1998) The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement. Sleep 21(1):52–66. Abstract The present investigation used a placebo-controlled, double-blind, crossover design to assess the sleep-promoting effect of three melatonin replacement delivery strategies in a group of patients with age-related sleep-maintenance insomnia. Subjects alternated between treatme

Keane KM, George TW, Constantinou CL, Brown MA, Clifford T, Howatson G. Effects of Montmorency tart cherry (Prunus Cerasus L.) consumption on vascular function in men with early hypertension Am J Clin Nutr. 2016 Abstract Background: Tart cherries contain numerous polyphenolic compounds that could potentially improve endothelial function and reduce cardiovascular disease risk. Objective: We sought to examine the acute effects of Montmorency tart cherry (MC) juice on vascular f

Kent K, Charlton KE, Jenner A, Roodenrys S. Acute reduction in blood pressure following consumption of anthocyanin-rich cherry juice may be dose-interval dependant: a pilot cross-over study. Int J Food Sci Nutr. Abstract A pilot cross-over study assessed the acute effects on blood pressure and plasma biomarkers associated with consumption of a 300 ml anthocyanin-rich fruit juice, provided in differing dose-intervals. Young adults (n = 6) and older adults (n = 7) received in r

Tjelle TE1, Holtung L1, Bøhn SK1, Aaby K2, Thoresen M3, Wiik SÅ1, Paur I1, Karlsen AS1, Retterstøl K1, Iversen PO1, Blomhoff R1 Polyphenol-rich juices reduce blood pressure measures in a randomised controlled trial in high normal and hypertensive volunteers. Br J Nutr. 2015 Oct 14;114(7):1054-63. doi: 10.1017/ S0007114515000562. Epub 2015 Abstract Intake of fruits and berries may lower blood pressure (BP), most probably due to the high content of polyphenols. In the present s

Phillip G. Bell, David C. Gaze, GarethW. Davison, TrevorW. George, Michael J. Scotter, Glyn Howatson Montmorency tart cherry (Prunus cerasus L.)concentrate lowers uric acid, independent of plasmacyanidin-3-O-glucosiderutinoside. Journal of Functional Foods, 2014. 82-90. Abstract Two doses (30 and 60 mL) of Montmorency tart cherry concentrate (MC) were used to investigate their impact on physiological indices of uric acid activity, inflammation and the bioavailability of the m

Lynn A, Mathew S, Moore CT, Russell J, Robinson E, Soumpasi V, Barker ME. Effect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: a randomised controlled trial Plant Foods Hum Nutr. 2014 Jun;69(2):122-7. doi: 10.1007/s11130-014-0409-x. Abstract Tart cherries are a particularly rich source of anthocyanins. Evidence indicates that dietary intake of anthocyanins is inversely associated with arterial stiffness. We conducted an open-label

Bell PG, Walshe IH, Davison GW, Stevenson E,Howatson G. Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling. Nutrients. 2014 Feb 21;6(2):829-43 Abstract This investigation examined the impact of Montmorency tart cherry concentrate (MC) on physiological indices of oxidative stress, inflammation and muscle damage across 3 days simulated road cycle racing. Trained cyclists (n = 16) were divided into equal

Schumacher HR, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage. 2013 Aug;21(8):1035-41. Abstract Objective: To assess the efficacy of tart cherry juice in treating pain and other features of knee osteoarthritis (OA). Methods: 58 non-diabetic patients with Kellgren grade 2-3 OA were randomized to begin treatmen

Howatson G, Bell PG, Tallent J, Middleton B, McHughMP, Ellis J. Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. Eur J Nutr.2012 Dec;51(8):909-16 Abstract Background: Tart Montmorency cherries have been reported to contain high levels of phytochemicals including melatonin, a molecule critical in regulating the sleep-wake cycle in humans. Purpose: The aim of our investigation was to ascertain whether ingestion of a tart cherry juice

Zhang, Y., Neogi, T., Chen, C., Chaisson, C., Hunter, D. J., & Choi,H. K. (2012). Cherry consumption and decreased risk of recurrent gout attacks. Arthritis and Rheumatism, 64, 4004–4011. Abstract Objective: To study the relationship between cherry intake and the risk of recurrent gout attacks among individuals with gout. Methods: We conducted a case-crossover study to examine the associations of a set of putative risk factors with recurrent gout attacks. Individuals with gou

Kuehl KS, Elliot DL, Sleigh A, Smith J. Efficacy of tart cherry juice to reduce inflammation biomarkers among women with inflammatory osteoarthritis. J Food Stud. 2012;1:14-25. Abstract Background Osteoarthritis (OA) is a major cause of pain and disability. OA patients may find relief from the inflammatory component of OA with NSAID use. Tart cherries, high in antioxidant and anti-inflammatory properties, may reduce pain and inflammation without the adverse side effects of NS

Schlesinger, N., Rabinowitz, R., & Schlesinger, M. (2012) Journal of Arthritis, 1, 1. Pilot studies of cherry juice concentrate for gout flare prophylaxis. Abstract The management of gout involves treating pain and inflammation associated with acute flares and lowering the uric acid pool. A challenge associated with the successful management of gout is an increased risk of acute flares after initiation of urate-lowering therapy (ULT). Prophylactic anti-inflammatory therapy i

Bowtell JL, Sumners DP, Dyer A, Fox P, Mileva K(2011) Montmorency cherry juice reduces muscle damage caused by intensive strength exercise. Med SciSports Exerc.43(8):1544– 1551 Abstract Purpose: Montmorency cherries contain high levels of polyphenolic compounds including flavonoids and anthocyanins possessing antioxidant and anti-inflammatory effects. We investigated whether the effects of intensive unilateral leg exercise on oxidative damage and muscle function were attenuat

Howatson G, McHugh MP, Hill JA, Brouner J, JewellAP, Van Someren KA, Shave RE, Howatson SA (2010) Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports. 20(6):843–852. Abstract This investigation determined the efficacy of a tart cherry juice in aiding recovery and reducing muscle damage, inflammation and oxidative stress. Twenty recreational Marathon runners assigned to either consumed cherry juice or placebo for 5 days befo

Pigeon WR, Carr M, Gorman C, Perlis ML. Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study. J Med Food. 2010 Jun;13(3):579-83. Abstract This study ascertained whether a proprietary tart cherry juice blend (CherryPharm, Inc., Geneva, NY, USA) associated with anecdotal reports of sleep enhancement improves subjective reports of insomnia compared to a placebo beverage. The pilot study used a randomized, double-blind, crossover desig

Kuehl K, Perrier E, Elliot D, Chesnutt J (2010) Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial. J Int Soc SportsNut. 7(1):17 Abstract Background: Long distance running causes acute muscle damage resulting in inflammation and decreased force production. Endurance athletes use NSAIDs during competition to prevent or reduce pain, which carries the risk of adverse effects. Tart cherries, rich in antioxidant and anti-inflammator

Chandra A, Nair MG, Iezzoni A. Evaluation andcharacterization of the anthocyanin pigments in tartcherries (Prunus cerasus L.). Journal of Agricultural andFood Chemistry.1992;40:976-969.